Description
Full Product Description for FOXO4-DRI 10mg
FOXO4-DRI (FOXO4-D-Retro-Inverso peptide) is a synthetic peptide designed to selectively induce apoptosis in senescent cells without affecting healthy, non-senescent cells. Senescent cells accumulate with age and contribute to age-related diseases, chronic inflammation, and tissue dysfunction. FOXO4-DRI represents a novel approach to senolytic therapy and healthy aging.
This 10mg vial contains a high-purity lyophilized FOXO4-DRI peptide, ideal for research and laboratory purposes investigating cellular senescence, aging-related disorders, and regenerative medicine.
Mechanism of Action:
FOXO4-DRI works by disrupting the interaction between the FOXO4 transcription factor and p53 protein in senescent cells. Under normal conditions, FOXO4 binds p53 in the nucleus, preventing apoptosis. The FOXO4-DRI peptide competitively inhibits this interaction, leading to the relocation of p53 and triggering programmed cell death in senescent cells.
Key Features:
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Senolytic Activity: Promotes apoptosis in senescent cells while sparing healthy ones
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Potential Anti-Aging Effects: Studied for improving tissue regeneration and reducing inflammation
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Research-Grade Quality: Synthesized under stringent quality control for laboratory use
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High Purity: ≥98% purity confirmed by HPLC, suitable for reliable and reproducible research
Applications in Research:
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Studies on aging and lifespan extension
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Investigation of age-related diseases (e.g., osteoarthritis, fibrosis, neurodegeneration)
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Cellular senescence and immune response modulation
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Experimental rejuvenation therapies and regenerative medicine
Reconstitution & Handling:
To reconstitute, add sterile bacteriostatic water or other suitable solvent to the vial and mix gently. Do not shake vigorously. Use aseptic techniques and handle under sterile conditions for optimal stability and performance.
