Description
Full Product Description: LL-37 5mg
LL-37 is a naturally occurring human antimicrobial peptide derived from the C-terminal end of the cathelicidin antimicrobial peptide (hCAP18). Known for its broad-spectrum antimicrobial and immunomodulatory properties, LL-37 plays a vital role in the innate immune response by defending against bacterial, viral, and fungal pathogens. The 5mg formulation provides a precise and consistent quantity suitable for experimental and clinical research.
Mechanism of Action:
LL-37 exerts its biological activity through disruption of microbial membranes, neutralization of endotoxins, and modulation of host cell responses. It also influences wound healing, tissue regeneration, angiogenesis, and inflammatory signaling, making it of high interest in studies involving infection control, dermatology, immunology, and tissue repair.
Key Research Applications:
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Antimicrobial Research: Demonstrates activity against Gram-positive and Gram-negative bacteria, as well as fungi and some viruses.
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Wound Healing: Shown to promote epithelial cell migration and angiogenesis in injury models.
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Inflammation Modulation: Regulates cytokine responses, macrophage function, and immune cell recruitment.
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Cancer Studies: Investigated for its dual role in tumor suppression and progression, depending on the context.
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Respiratory and Gastrointestinal Research: Explored for roles in chronic inflammatory conditions like asthma, COPD, and IBD.
Storage & Stability:
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Store lyophilized peptide at -20°C in a dry, dark place.
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Once reconstituted with bacteriostatic water or sterile saline, store at 2–8°C and use within 20 days for best stability.
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Avoid repeated freeze-thaw cycles.
Reconstitution Guidelines:
Add sterile water (typically 1–2ml) to the vial to achieve desired concentration. Gently swirl (do not shake) until the powder is fully dissolved.
